HER2 Support Group Forums - View Single Post - Study confirms tamoxifen is superior to fulvestrant in blocking estrogen

Becky · 08-21-2011, 05:52 AM

Okay - I read the full study elsewhere. In the study, they were studying estrogen blocking more than estrogen depleting. They gave patients radioactive estrogen and then scanned them. Of course an AI would do more poorly because an AI prevents the synthesis of estrogen in the body and the researchers were giving estrogen. However, it is a good study in relation to which drug blocks estrogen better.

It was difficult to comprehend that with all the studies on the 3 AIs, all concluding that an AI is better than Tamoxifen, that this study would say differently and the reason is the study gives estrogen so those taking an AI would of course have uptake since in theory, their bodies can't make estrogen.

08-21-2011, 05:52 AM	#5
Becky Senior Member Join Date: Sep 2005 Location: Stockton, NJ Posts: 4,179	Re: Study confirms tamoxifen is superior to fulvestrant in blocking estrogen Okay - I read the full study elsewhere. In the study, they were studying estrogen blocking more than estrogen depleting. They gave patients radioactive estrogen and then scanned them. Of course an AI would do more poorly because an AI prevents the synthesis of estrogen in the body and the researchers were giving estrogen. However, it is a good study in relation to which drug blocks estrogen better. It was difficult to comprehend that with all the studies on the 3 AIs, all concluding that an AI is better than Tamoxifen, that this study would say differently and the reason is the study gives estrogen so those taking an AI would of course have uptake since in theory, their bodies can't make estrogen. __________________ Kind regards Becky Found lump via BSE Diagnosed 8/04 at age 45 1.9cm tumor, ER+PR-, Her2 3+(rt side) 2 micromets to sentinel node Stage 2A left 3mm DCIS - low grade ER+PR+Her2 neg lumpectomies 9/7/04 4DD AC followed by 4 DD taxol Used Leukine instead of Neulasta 35 rads on right side only 4/05 started Tamoxifen Started Herceptin 4 months after last Taxol due to trial results and 2005 ASCO meeting & recommendations Oophorectomy 8/05 Started Arimidex 9/05 Finished Herceptin (16 months) 9/06 Arimidex Only Prolia every 6 months for osteopenia NED 18 years! Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"