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pattyz · 11-07-2006, 08:38 AM

Ceesun,

I know of gals who developed brain mets while on a course of Xeloda.

Xeloda alone showed a good response for a gal whom my onc treats for bc brain mets. Her OTHER mets progressed, however.

Xeloda is technically small enough, molecular wgt wise, to cross the bbb. There is also the 'leaky bbb' to consider, caused by rads, tumors themselves and ???

Xeloda is being used as a trial drug with other drugs for brain mets. Why would they use it if they didn't believe it did indeed have the potential to cross the bbb?

In my own case, I've been using it in conjunction with Temodar, fairly successfully for the past 18 months to control my current 8 brain mets.

I know, more info that you were looking for, and I apologize for that.

This will most likely be a case where YOUR answer lies somewhere in the 'every one is different' catagory.....

best wishes to you,
pattyz

11-07-2006, 08:38 AM	#4
pattyz Senior Member Join Date: Mar 2006 Posts: 306	Ceesun, I know of gals who developed brain mets while on a course of Xeloda. Xeloda alone showed a good response for a gal whom my onc treats for bc brain mets. Her OTHER mets progressed, however. Xeloda is technically small enough, molecular wgt wise, to cross the bbb. There is also the 'leaky bbb' to consider, caused by rads, tumors themselves and ??? Xeloda is being used as a trial drug with other drugs for brain mets. Why would they use it if they didn't believe it did indeed have the potential to cross the bbb? In my own case, I've been using it in conjunction with Temodar, fairly successfully for the past 18 months to control my current 8 brain mets. I know, more info that you were looking for, and I apologize for that. This will most likely be a case where YOUR answer lies somewhere in the 'every one is different' catagory..... best wishes to you, pattyz