[Rich66]

Interesting insight, Bejuce.
Hadn't thought of neoadjuvant tx as a method to reduce overall trauma from surgery. For what it's worth, I spoke at length with a woman with a large breast tumor who claims to have skipped surgery and pursued IPT because it was considered aggressive, essentially hopeless tumor. Initial thought was surgery wouldn't help so try to keep it under control while maintaining quality of life. She says it has grown and shrunk over a good number of years ( I think 5+) but hasn't spread. Completely anecdotal, but pretty provocative.
However...
Considering known release of growth factors from surgery trauma and contributing issues with the typically general opiate anesthesia (and post surgery opiates), makes me wonder.