HER2 Support Group Forums - View Single Post - Herceptin may be effective even for low HER-2 expression(in vitro studies)

heblaj01 · 08-12-2006, 06:07 PM

http://www.jco.org/cgi/content/abstract/24/23/3735

Trastuzumab in Combination With Heregulin-Activated Her-2 (erbB-2) Triggers a Receptor-Enhanced Chemosensitivity Effect in the Absence of Her-2 Overexpression

Javier A. Menendez, Inderjit Mehmi, Ruth Lupu
JCO Aug 10 2006: 3735-3746.

http://www.jco.org/cgi/content/full/24/23/3722

Journal of Clinical Oncology, Vol 24, No 23 (August 10), 2006: pp. 3722-3725
Can Trastuzumab Be Effective Against Tumors With Low HER2/Neu (ErbB2) Receptors?

The first article details the lab studies indicating that Herceptin+chemo might be still effective in certain cases even when HER-2 is not strongly positive.
The second article discusses this & other related findings.

If these studies were to be confirmed in patients it would give oncs who already continue to prescribe Herceptin even after it appears to loose potency more reasons to do so.

08-12-2006, 06:07 PM	#1
heblaj01 Senior Member Join Date: Apr 2006 Posts: 543	Herceptin may be effective even for low HER-2 expression(in vitro studies) http://www.jco.org/cgi/content/abstract/24/23/3735 *Trastuzumab in Combination With Heregulin-Activated Her-2 (erbB-2) Triggers a Receptor-Enhanced Chemosensitivity Effect in the Absence of Her-2 Overexpression* Javier A. Menendez, Inderjit Mehmi, Ruth Lupu JCO Aug 10 2006: 3735-3746. http://www.jco.org/cgi/content/full/24/23/3722 Journal of Clinical Oncology, Vol 24, No 23 (August 10), 2006: pp. 3722-3725 Can Trastuzumab Be Effective Against Tumors With Low HER2/Neu (ErbB2) Receptors? The first article details the lab studies indicating that Herceptin+chemo might be still effective in certain cases even when HER-2 is not strongly positive. The second article discusses this & other related findings. If these studies were to be confirmed in patients it would give oncs who already continue to prescribe Herceptin even after it appears to loose potency more reasons to do so.