HER2 Support Group Forums - View Single Post - COX2 and BC a cumulative knowledge thread

R.B. · 11-05-2007, 06:13 PM

I read this a while ago. It is a fascinating and informative article.

RB

Relationship between aromatase and cyclooxygenases in breast cancer: potential for new therapeutic approaches.
Brueggemeier RW, DÃ*az-Cruz ES.

Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA. Brueggemeier.1@osu.edu

"High levels of COX-2 expression result in higher levels of prostaglandin E2 (PGE2), which in turn increases CYP19 expression through increases in intracellular cyclic AMP levels and activation of promoter II. Thus, PGE2 produced by COX enzymes may act locally in paracrine and autocrine fashion to increase the biosynthesis of estrogen by aromatase in hormone-dependent breast cancer development."

11-05-2007, 06:13 PM	#5
R.B. Senior Member Join Date: Mar 2006 Posts: 1,843	I read this a while ago. It is a fascinating and informative article. RB Relationship between aromatase and cyclooxygenases in breast cancer: potential for new therapeutic approaches. Brueggemeier RW, DÃ*az-Cruz ES. Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA. Brueggemeier.1@osu.edu "High levels of COX-2 expression result in higher levels of prostaglandin E2 (PGE2), which in turn increases CYP19 expression through increases in intracellular cyclic AMP levels and activation of promoter II. Thus, PGE2 produced by COX enzymes may act locally in paracrine and autocrine fashion to increase the biosynthesis of estrogen by aromatase in hormone-dependent breast cancer development."