HER2 Support Group Forums - View Single Post - COX2 and BC a cumulative knowledge thread

R.B. · 11-05-2007, 05:34 PM

Thought provoking indeed.

RB

HER-2/neu status is a determinant of mammary aromatase activity in vivo: evidence for a cyclooxygenase-2-dependent mechanism.
Subbaramaiah K, Howe LR, Port ER, Brogi E, Fishman J, Liu CH, Hla T, Hudis C, Dannenberg AJ.

Department of Medicine, Weill Medical College of Cornell University, New York, NY, USA.

http://www.ncbi.nlm.nih.gov/sites/en...ubmed_RVDocSum

"Previously, we found that overexpression of HER-2/neu was associated with increased levels of COX-2 in human breast cancers. Here, we show that overexpression of HER-2/neu is also associated with increased aromatase activity. These results suggested the possibility that COX-2 was the functional intermediate linking HER-2/neu and aromatase......Collectively, our data indicate that COX-2 is the functional intermediate linking HER-2/neu and aromatase and suggest that inhibitors of PGE(2) synthesis will suppress estrogen biosynthesis in breast tissue."

11-05-2007, 05:34 PM	#4
R.B. Senior Member Join Date: Mar 2006 Posts: 1,843	COX-2 is the functional intermediate linking HER-2/neu and aromatase Thought provoking indeed. RB HER-2/neu status is a determinant of mammary aromatase activity in vivo: evidence for a cyclooxygenase-2-dependent mechanism. Subbaramaiah K, Howe LR, Port ER, Brogi E, Fishman J, Liu CH, Hla T, Hudis C, Dannenberg AJ. Department of Medicine, Weill Medical College of Cornell University, New York, NY, USA. http://www.ncbi.nlm.nih.gov/sites/en...ubmed_RVDocSum "Previously, we found that overexpression of HER-2/neu was associated with increased levels of COX-2 in human breast cancers. Here, we show that overexpression of HER-2/neu is also associated with increased aromatase activity. These results suggested the possibility that COX-2 was the functional intermediate linking HER-2/neu and aromatase......Collectively, our data indicate that COX-2 is the functional intermediate linking HER-2/neu and aromatase and suggest that inhibitors of PGE(2) synthesis will suppress estrogen biosynthesis in breast tissue."