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R.B. · 11-05-2007, 05:29 PM

Reduced BRAC1 increases aromatase products.

It looks as if BRAC 1 may act as an aromatase inhibitor (and when BRAC1 mutates does it stop doing that ? - this seems to be the question being asked between the lines)

BRCA1 negatively regulates the cancer-associated aromatase promoters I.3 and II in breast adipose fibroblasts and malignant epithelial cells.
Lu M, Chen D, Lin Z, Reierstad S, Trauernicht AM, Boyer TG, Bulun SE.

http://www.ncbi.nlm.nih.gov/sites/en...ubmed_RVDocSum

Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA.

"CONCLUSIONS: Selective inhibition of aromatase expression by BRCA1 binding to the I.3/II tumorigenic promoter region may be an important protective mechanism against breast cancer development."

11-05-2007, 05:29 PM	#3
R.B. Senior Member Join Date: Mar 2006 Posts: 1,843	Reduced BRAC1 increases aromatase products. It looks as if BRAC 1 may act as an aromatase inhibitor (and when BRAC1 mutates does it stop doing that ? - this seems to be the question being asked between the lines) BRCA1 negatively regulates the cancer-associated aromatase promoters I.3 and II in breast adipose fibroblasts and malignant epithelial cells. Lu M, Chen D, Lin Z, Reierstad S, Trauernicht AM, Boyer TG, Bulun SE. http://www.ncbi.nlm.nih.gov/sites/en...ubmed_RVDocSum Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA. "CONCLUSIONS: Selective inhibition of aromatase expression by BRCA1 binding to the I.3/II tumorigenic promoter region may be an important protective mechanism against breast cancer development."