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agness · 01-21-2016, 10:22 PM

I am using the ketogenic diet to lower my blood and brain glucose levels. So far my body is really happy about it.

Metformin is used a lot for women with PCOS dealing with fertility issues but my sense was that insulin resistance was at play for the development of breast cancer as well. Lots of stage 4 BC sisters are on metformin and tolerating it well. I think if you ask on Inspire.com you might find more.

I think if we think about cancer as a metabolic disease that we are fighting then it makes a lot of sense to switch to a less favorable diet, one that makes cancer grumpy. It has been part of my modus operandi -- making my brain mets uncomfortable

BTW, I found this great article that is very relevant to this discussion:

An integrated multidisciplinary model describing initiation of cancer and the Warburg hypothesis
http://www.tbiomed.com/content/10/1/39

They think glucose dysregulation happens first, then cancer develops.

This also mentions that weekly dosing (metronomic, dose-dense) of certain chemo agents might work better based on cell cycle dynamics.

01-21-2016, 10:22 PM	#6
agness Senior Member Join Date: Aug 2014 Location: Seattle, WA Posts: 285	Re: Do you take Metformin? I am using the ketogenic diet to lower my blood and brain glucose levels. So far my body is really happy about it. Metformin is used a lot for women with PCOS dealing with fertility issues but my sense was that insulin resistance was at play for the development of breast cancer as well. Lots of stage 4 BC sisters are on metformin and tolerating it well. I think if you ask on Inspire.com you might find more. I think if we think about cancer as a metabolic disease that we are fighting then it makes a lot of sense to switch to a less favorable diet, one that makes cancer grumpy. It has been part of my modus operandi -- making my brain mets uncomfortable BTW, I found this great article that is very relevant to this discussion: An integrated multidisciplinary model describing initiation of cancer and the Warburg hypothesis http://www.tbiomed.com/content/10/1/39 They think glucose dysregulation happens first, then cancer develops. This also mentions that weekly dosing (metronomic, dose-dense) of certain chemo agents might work better based on cell cycle dynamics. __________________ Dx 2/14 3b HER2+/HR- left breast, left axilla, internal mammary node (behind breast bone). Neoadjuvant TCHP 3/14-7/2. PCR 8/14 LX and SND. 10/21-12/9 Proton therapy to chest wall. Dx 7/20/15 cerebellar met 3.5x5cm HER2+/HR-/GATA3+ 7/23/15 Craniotomy. 7/29/15 bone scan clear. 8/3/15 PET clean scan. LINAC SRS (5 fractions) Sept 2015. 9/17/15 CSF NED, 9/24/15 CSF NED, 11/2/15 CSF NED. 10/27/15 atypical uptake in right cerebellum - inflammation? 12/1/15 Leptomeningeal dx. Starting IT Herceptin. 1/16 - 16 fractions of tomotherapy to cerebellum, break of IT Herceptin during rads, resume at 100 mg weekly 3/2016 - stable scan 5/2016 stable scan 7/2016 pseudoprogression? 9/2016 more LM, start new chemo protocol and IV therapy treatment with HBOT 11/2016 Cyberknife to temporal lobe, HBOT just prior 12/2016 - lesions starting to show shrinkage 8/2017 - Stable since Dec 2016. Temporal lobe lesion gone. Using TCM, naturopathic oncology, physical therapy, chiro, massage, medical qigong, and energetic healing modalities in tandem. Stops at nothing. Mother of 2 boys - ages 7 and 10 (8/2017) and a lovely partner with lots to live for. Last edited by agness; 01-21-2016 at 10:22 PM.. Reason: typo