HER2 Support Group Forums - View Single Post - Diabetes medication could be effective therapy for aggressive type of breast cancer

donocco · 03-14-2017, 01:06 PM

I looked up the drug and got a bit of info. Epalrestat as far as diabetes goes is not a blood
sugar lowering drug. It is an Aldose reductase inhibitor and this class of drugs inhibits the production of Sorbitol a type of sugar. Sorbitol is important in the development of the Diabetic nerve complications. I think the dose is 150mg daily.I dont know if other anti-sorbitol drugs have an anti-breast cancer effect. Im not sure any anti-sorbitol drugs are FDA approved. Lipoic Acid has been used in europe to treat diabetic retinopathy. Ill check to see if Lipoic Acid has any action against AKR1b1.

Paul

03-14-2017, 01:06 PM	#2
donocco Senior Member Join Date: Oct 2013 Posts: 474	Re: Diabetes medication could be effective therapy for aggressive type of breast canc I looked up the drug and got a bit of info. Epalrestat as far as diabetes goes is not a blood sugar lowering drug. It is an Aldose reductase inhibitor and this class of drugs inhibits the production of Sorbitol a type of sugar. Sorbitol is important in the development of the Diabetic nerve complications. I think the dose is 150mg daily.I dont know if other anti-sorbitol drugs have an anti-breast cancer effect. Im not sure any anti-sorbitol drugs are FDA approved. Lipoic Acid has been used in europe to treat diabetic retinopathy. Ill check to see if Lipoic Acid has any action against AKR1b1. Paul