HER2 Support Group Forums - View Single Post - PARP trial

swanky · 09-30-2007, 06:01 PM

Marcia - I never thought it of it that way, but you're right! Long story short, the PARP inhibitor helps correct the DNA mutation that BRCA+'s have and ultimately causes our tumors. A major over simplification, but basically repairs my DNA. The best thing? No side effects yet...I have taken the 8 pills twice a day for over two months now and am fine. Maybe a little fatigued, but can't say if that is the drug or my rather energetic family.

09-30-2007, 06:01 PM	#15
swanky Senior Member Join Date: Jul 2007 Location: Bakersfield, CA Posts: 38	Marcia - I never thought it of it that way, but you're right! Long story short, the PARP inhibitor helps correct the DNA mutation that BRCA+'s have and ultimately causes our tumors. A major over simplification, but basically repairs my DNA. The best thing? No side effects yet...I have taken the 8 pills twice a day for over two months now and am fine. Maybe a little fatigued, but can't say if that is the drug or my rather energetic family. __________________ Age 33 at dx - 9/15/06 L breast, Invasive solid DC w/ extensive DCIS, Grade 3, ER/PR negative/ HER2 neu positive (barely) -AC DD, taxotere, taxol w/ herceptin -Bi lat 1/18/07, multiple foci of IDC admixed with DCIS, IDC varied from 0.1, 0.5, and up to 1.6 cm, 1/19 + nodes Expanders in place Pregnant when dx Mom to 4 beautiful kiddos (boys: 5 and 14 mos, girls: 17 and 3) Recurrence in neck lymph node and 8mm spot in L breast above expander, herceptin stopped BRCA 1 positive Clinical trial since 7/23/07 (PARP INHIBITOR)-NED for 9 months, supraclavicle node popped back up,..so we cut it out! Full neck dissection - only 1 positive node ER/PR negative and now HER2 negative Currently on Xeloda and NED