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Tamoxifen itself is a big issue for Her2+ ER+ bc, in that it has been shown in some studies to be stimulatory for this type of breast cancer. Combining Herceptin with Tamoxifen seems to ameliorate this effect, however, the duration of Herceptin treatment is one year and the duration of tamoxifen treatment is 5 years. THAT, IMO, is an issue.
Hopeful
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