HER2 Support Group Forums - View Single Post - HER2+, ER+, PR+ and are taking Tamoxifen.

AlaskaAngel · 06-21-2006, 07:57 AM

The lecture sounds very interesting. Thanks for sharing it and explaining it so well.

I still have a few questions about it. Maybe someone who understands cross-talk better than I do could comment on them.

1. Herceptin doesn't work on some varieties of HER positivity other than HER2. So would there still be a problem in terms of cross-talk and tamoxifen, as long as HER2 was blocked by Herceptin?

2. Apparently Herceptin does not work for a significant number of those who are HER2 positive, or who become resistant to Herceptin. Would there still be a problem in terms of cross-talk and use of tamoxifen for them?

A.A.

06-21-2006, 07:57 AM	#9
AlaskaAngel Senior Member Join Date: Sep 2005 Location: Alaska Posts: 2,018	Questions The lecture sounds very interesting. Thanks for sharing it and explaining it so well. I still have a few questions about it. Maybe someone who understands cross-talk better than I do could comment on them. 1. Herceptin doesn't work on some varieties of HER positivity other than HER2. So would there still be a problem in terms of cross-talk and tamoxifen, as long as HER2 was blocked by Herceptin? 2. Apparently Herceptin does not work for a significant number of those who are HER2 positive, or who become resistant to Herceptin. Would there still be a problem in terms of cross-talk and use of tamoxifen for them? A.A.