[R.B.]

75% of a group of early cancer sufferers were either vit d insufficient or plain deficient !, which is scary given the importance of vitamin D, and its wider involvement in cellular function than is generally realised


J Clin Oncol. 2009 Aug 10;27(23):3757-63. Epub 2009 May 18.
Prognostic effects of 25-hydroxyvitamin D levels in early breast cancer.
Goodwin PJ, Ennis M, Pritchard KI, Koo J, Hood N.
Source

Mount Sinai Hospital, 1284-600 University Ave, Toronto, Ontario M5G 1X4, Canada. pgoodwin@mtsinai.on.ca
Abstract
PURPOSE:

Vitamin D has been linked to breast cancer risk, but prognostic effects are unknown. Such effects are biologically plausible given the presence of vitamin D receptors in breast cancer cells, which act as nuclear transcription factors to regulate gene activity.
PATIENTS AND METHODS:

The study was conducted in a prospective inception cohort of 512 women with early breast cancer diagnosed 1989 to 1996. Vitamin D levels were measured in stored blood. Clinical, pathologic, and dietary data were accessed to examine prognostic effects of vitamin D.
RESULTS:

Mean age was 50.4 years, mean vitamin D was 58.1 +/- 23.4 nmol/L. Vitamin D levels were deficient (< 50 nmol/L) in 37.5% of patients, insufficient (50 to 72 nmol/L) in 38.5% of patients, and sufficient (> 72 nmol/L) in 24.0% of patients. There was little variation in mean vitamin D levels between summer and winter months. Mean follow-up was 11.6 years; 116 women had distant recurrences, and 106 women died. Women with deficient vitamin D levels had an increased risk of distant recurrence (hazard ratio [HR] = 1.94; 95% CI, 1.16 to 3.25) and death (HR = 1.73; 95% CI, 1.05 to 2.86) compared with those with sufficient levels. The association remained after individual adjustment for key tumor and treatment related factors but was attenuated in multivariate analyses (HR = 1.71; 95% CI, 1.02 to 2.86 for distant recurrence; HR = 1.60; 95% CI, 0.96 to 2.64 for death).