HER2 Support Group Forums - View Single Post - Vitamin D thread -Please use this for your Vit D info.

R.B. · 10-02-2011, 03:22 PM

Serum 25-hydroxyvitamin D is inversely associated with body mass index in cancer
Pankaj G Vashi,1 Carolyn A Lammersfeld,1 Donald P Braun,1 and Digant Guptacorresponding author1
1Cancer Treatment Centers of America® (CTCA) at Midwestern Regional Medical Center, 2520 Elisha Avenue, Zion, IL, 60099, USA

http://www.ncbi.nlm.nih.gov/pmc/arti...4/?tool=pubmed

(Full Free Text)

"Conclusions
Obese cancer patients (BMI >= 30 kg/m2) had significantly lower levels of serum 25(OH)D as compared to non-obese patients (BMI <30 kg/m2). BMI should be taken into account when assessing a patient's vitamin D status and more aggressive vitamin D supplementation should be considered in obese cancer patients.

Background
Serum 25-hydroxyvitamin D [25(OH)D] is the major circulating form of vitamin D and a standard indicator of vitamin D status [1,2]. Several studies have described an inverse relationship between serum 25(OH)D and cancer risk [3-5]. The relationship between regular vitamin D intake and reduced cancer incidence has also been reported [6]. Furthermore, higher plasma 25(OH)D levels are associated with improved survival in prostate [7], breast [8], lung [9], colorectal [10] and ovarian [11] cancers. A better vitamin D status at the time of diagnosis and treatment, adjusted for season of diagnosis, has been shown to improve survival [12,13].
Several factors are involved in the regulation of 25(OH)D including: age; gender [14]; race [15]; dietary intake [2]; season [16]; and sunlight exposure [17]. Recently, the relationship between obesity and vitamin D status has been investigated suggesting decreased bioavailability of 25(OH)D from cutaneous and dietary sources in association with obesity [18]. "

10-02-2011, 03:22 PM	#23
R.B. Senior Member Join Date: Mar 2006 Posts: 1,843	Re: Vitamin D thread -Please use this for your Vit D info. Serum 25-hydroxyvitamin D is inversely associated with body mass index in cancer Pankaj G Vashi,1 Carolyn A Lammersfeld,1 Donald P Braun,1 and Digant Guptacorresponding author1 1Cancer Treatment Centers of America® (CTCA) at Midwestern Regional Medical Center, 2520 Elisha Avenue, Zion, IL, 60099, USA http://www.ncbi.nlm.nih.gov/pmc/arti...4/?tool=pubmed (Full Free Text) "Conclusions Obese cancer patients (BMI >= 30 kg/m2) had significantly lower levels of serum 25(OH)D as compared to non-obese patients (BMI <30 kg/m2). BMI should be taken into account when assessing a patient's vitamin D status and more aggressive vitamin D supplementation should be considered in obese cancer patients. Background Serum 25-hydroxyvitamin D [25(OH)D] is the major circulating form of vitamin D and a standard indicator of vitamin D status [1,2]. Several studies have described an inverse relationship between serum 25(OH)D and cancer risk [3-5]. The relationship between regular vitamin D intake and reduced cancer incidence has also been reported [6]. Furthermore, higher plasma 25(OH)D levels are associated with improved survival in prostate [7], breast [8], lung [9], colorectal [10] and ovarian [11] cancers. A better vitamin D status at the time of diagnosis and treatment, adjusted for season of diagnosis, has been shown to improve survival [12,13]. Several factors are involved in the regulation of 25(OH)D including: age; gender [14]; race [15]; dietary intake [2]; season [16]; and sunlight exposure [17]. Recently, the relationship between obesity and vitamin D status has been investigated suggesting decreased bioavailability of 25(OH)D from cutaneous and dietary sources in association with obesity [18]. "