HER2 Support Group Forums - View Single Post - Vitamin D & Breast Cancer 50% - 70% risk reductions

R.B. · 10-10-2013, 03:10 PM

Global indeed ! No wonder Professor Holick

is a little acerbic in his vitamin D video above !

Arab pre-term infants often have less than 10 ng of vitamin D - 2010
High Prevalence of moderately severe vitamin D deficiency in Pre-Term Infants

Received: 25-Nov-2009, revised: 17-May-2010, accepted: 16-Jun-2010
Original Article: Clinical Investigation
Adekunle Dawodu, MBBS, FRCPCH1, Ravi Nath, FRCPCH2
1Global Health Center, Cincinnati Children’s Hospital Medical Center
2Department of Pediatrics, Al-Ain Hospital, Al-Ain, United Arab Emirates
Adekunle Dawodu, MD
Cincinnati Children’s Hospital Medical Center
3333 Burnet Avenue, MLC 2048
Cincinnati, OH 45229 adekunle.dawodu@cchmc.org

Abstract
Background: The recommended dose of vitamin D (vD) supplementation of preterm infants is based on data from populations in which severe vD deficiency is uncommon and may be inadequate for infants in high risk population. However, data on vD status of preterm infants in high risk populations, such as Middle Eastern countries is scarce.
Aim: Investigate the vD status of Arab mothers and their preterm infants.

Method: Maternal serum and cord blood 25(OH)D, Ca, P and ALP were measured at delivery. Serum 25(OH)D was measured by HPLC while the other biochemical parameters were measured by standard autoanalyzer.

Results: Thirty-four preterm infants were studied. The mean gestational age was 31.4 weeks and birth weight was 1667g. The median serum 25(OH)D of 17.0 nmol/L in 28 mothers and 14.5 nmol/L in 34 cord blood samples were low. The median maternal and cord blood Ca, P and ALP levels were within normal range. Fifteen (44%) of the infants had moderately severe vD deficiency (serum 25 (OH)D levels <12.5 nmol/L). The median serum 25(OH)D levels of mothers who had reportedly taken prenatal vD supplementation and those who had not were similar (17.3 vs 16.3) nmol/L. The mean serum 25(OH)D levels among preterm infants in this study were low when compared to levels in Caucasians preterm infants on which the current vD recommendations are based. Conclusion: The high prevalence of moderately severe vD deficiency in Arab preterm infants provides a justification to investigate vD requirement of preterm infants in this and other high risk populations.

10-10-2013, 03:10 PM	#19
R.B. Senior Member Join Date: Mar 2006 Posts: 1,843	Re: Vitamin D & Breast Cancer 50% - 70% risk reductions - authoritative must watch vi Global indeed ! No wonder Professor Holick is a little acerbic in his vitamin D video above ! Arab pre-term infants often have less than 10 ng of vitamin D - 2010 High Prevalence of moderately severe vitamin D deficiency in Pre-Term Infants Received: 25-Nov-2009, revised: 17-May-2010, accepted: 16-Jun-2010 Original Article: Clinical Investigation Adekunle Dawodu, MBBS, FRCPCH1, Ravi Nath, FRCPCH2 1Global Health Center, Cincinnati Children’s Hospital Medical Center 2Department of Pediatrics, Al-Ain Hospital, Al-Ain, United Arab Emirates Adekunle Dawodu, MD Cincinnati Children’s Hospital Medical Center 3333 Burnet Avenue, MLC 2048 Cincinnati, OH 45229 adekunle.dawodu@cchmc.org Abstract Background: The recommended dose of vitamin D (vD) supplementation of preterm infants is based on data from populations in which severe vD deficiency is uncommon and may be inadequate for infants in high risk population. However, data on vD status of preterm infants in high risk populations, such as Middle Eastern countries is scarce. Aim: Investigate the vD status of Arab mothers and their preterm infants. Method: Maternal serum and cord blood 25(OH)D, Ca, P and ALP were measured at delivery. Serum 25(OH)D was measured by HPLC while the other biochemical parameters were measured by standard autoanalyzer. Results: Thirty-four preterm infants were studied. The mean gestational age was 31.4 weeks and birth weight was 1667g. The median serum 25(OH)D of 17.0 nmol/L in 28 mothers and 14.5 nmol/L in 34 cord blood samples were low. The median maternal and cord blood Ca, P and ALP levels were within normal range. Fifteen (44%) of the infants had moderately severe vD deficiency (serum 25 (OH)D levels <12.5 nmol/L). The median serum 25(OH)D levels of mothers who had reportedly taken prenatal vD supplementation and those who had not were similar (17.3 vs 16.3) nmol/L. The mean serum 25(OH)D levels among preterm infants in this study were low when compared to levels in Caucasians preterm infants on which the current vD recommendations are based. Conclusion: The high prevalence of moderately severe vD deficiency in Arab preterm infants provides a justification to investigate vD requirement of preterm infants in this and other high risk populations. Last edited by R.B.; 10-10-2013 at 03:22 PM..