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Christine MH-UK · 05-16-2007, 12:24 PM

See:

Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis.
http://www.ncbi.nlm.nih.gov/entrez/q...=pubmed_docsum

and

Protein-tyrosine phosphatase 1B is required for HER2/Neu-induced breast cancer.

http://www.ncbi.nlm.nih.gov/entrez/q..._uids=17347513

I could only find diabetes trials for two inhibitors, ISIS-113715 and Ertiprotafib. I am sure that Lani knows of more! Of course, the nice thing is that these have already been through the time consuming phase I trials.

A computer buddy of mine has just been diagnosed with lung mets, even though she had herceptin after chemo, so it's good to know that there is a lead in this area.

05-16-2007, 12:24 PM	#2
Christine MH-UK Senior Member Join Date: Sep 2005 Posts: 414	her2 connection may even be stronger than article suggests See: Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis. http://www.ncbi.nlm.nih.gov/entrez/q...=pubmed_docsum and Protein-tyrosine phosphatase 1B is required for HER2/Neu-induced breast cancer. http://www.ncbi.nlm.nih.gov/entrez/q..._uids=17347513 I could only find diabetes trials for two inhibitors, ISIS-113715 and Ertiprotafib. I am sure that Lani knows of more! Of course, the nice thing is that these have already been through the time consuming phase I trials. A computer buddy of mine has just been diagnosed with lung mets, even though she had herceptin after chemo, so it's good to know that there is a lead in this area.