|
Re: How does Perjeta work?
Perjeta works by preventing the dimerization (linking) of the Her 2 protein with Her3 and Her 4 proteins. When the Her 2 protein links with the other growth factors, certain signal mechanisms like Map Kinase and PI-3K start a chain of events (A-B-C-D-E-F etc ) that ultimately reach the cell nucleus and initiate cell growth. This A-B-C-etc- to cell growth is known as signal transduction. Perjeta by preventing the dimerization process decreases this. Hope this helps.
Paul
|