[annmask]

My neighbor was DX stage 4 brain mets only after completing stage 3 treatments. After successful treatment she was on Tykerb and Herceptin for 2 years, then Tykerb only (6 per day), and after 2 more years is down to 2 tykerb per day, still NED, and feeling great. Sounds like you had an even lower tumor load at the onset....maybe another 2nd opinion? My belief is that if it makes you feel bad, it is probably somewhat harmful to the radiantly healthy majority of our cells, so if there is a doubt, I would ask for yet another opinion from a doc at a major cancer center that specializes in HER2+ BC.