HER2 Support Group Forums - View Single Post - could a cox2 inhibitor replace antihormonals in her2neu+ breast cancer therapy?

Lani · 08-26-2006, 04:19 AM

There is no money to be made, research required or safety to be proved with tumeric, so little research will probably be done regarding its effects in a dose related fashion(some compounds have opposite effects when given in higher or lesser doses), in different age groups, in people with different ways to metabolize the compounds, or in combination with different medications, in those with compromised liver or kidney function, etc.

Lots of work has been done on NSAIDS especially those that have been on the market for over 25 years (clinoril, naprosyn, ibuprofen, etc) Naprosyn seems to be the one they are now using as the one to compare against with respect to safety (ie, the one considered the safest) in my review of the recent literature.

Remember there are two other enzymes besides aromatase (actually more because they have subsets of enzymes) involved in the local production of estradiol or estrone in the breast cancer cells or their immediate local microenvironment.

There is a lot still to work out here...

08-26-2006, 04:19 AM	#3
Lani Senior Member Join Date: Mar 2006 Posts: 4,778	don't really know haven't looked into it , but I doubt anyone has There is no money to be made, research required or safety to be proved with tumeric, so little research will probably be done regarding its effects in a dose related fashion(some compounds have opposite effects when given in higher or lesser doses), in different age groups, in people with different ways to metabolize the compounds, or in combination with different medications, in those with compromised liver or kidney function, etc. Lots of work has been done on NSAIDS especially those that have been on the market for over 25 years (clinoril, naprosyn, ibuprofen, etc) Naprosyn seems to be the one they are now using as the one to compare against with respect to safety (ie, the one considered the safest) in my review of the recent literature. Remember there are two other enzymes besides aromatase (actually more because they have subsets of enzymes) involved in the local production of estradiol or estrone in the breast cancer cells or their immediate local microenvironment. There is a lot still to work out here...