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Re: Desensitization protocol
SCG
These procedures have been around for decades. I didnt know they were using them for chemos. Ill tell you the theory of them so you will understand more about them.
It really started with people allergic to penicillin. When a severly allergic penicillin patient gets penicillin by mistake you have an antibody reaction based on an antibody called IGE. There are a number of these IG antibodies ie IGM IGA and IGG. IGG is the famous gamma globulin.
It is the IGE antibodies that are involved in anaphylactic reactions. When you do a desensitization prodedure you give very low doses of the medicine to start. Each day you raise the dose slightly until you reach the therapeutic dose. You dont stop being allergic to the medication but by gradually increasing the dose slowly, you get an IGG reaction instead of an IGE reaction so there is no anaphylaxis. As long as you stay on the medicine after doing the desensitization your allergic reaction will stay IGG. If you stop it you go back to an IGE reaction with anaphylaxis. Hope this "lecture" is helpful. Merry Christmas to all
Paul
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