HER2 Support Group Forums - View Single Post - The traditional diet of Greece and cancer.

R.B. · 06-14-2008, 03:31 PM

More evidence Omega 6 LA is implicated in BC.

And why COX blockers may have an impact as the block these pathways.

And more PGE2 may = more aromatase = more oestrogen products

More oestrogen would result in more conversion of LA to AA the raw material for this process be enhancing long chain fat conversion.

SO this could be a self fuelling tumour loop where Omega 6 is present in excess and there is no Omega 3 to moderate the process.

RB

http://www.springerlink.com/content/n547j2538p317388/

Xin-Hua Liu1, Jeanne M. Connolly1 and David P. Rose1 Contact Information
(1) Division of Nutrition and Endocrinology, American Health Foundation, Valhalla, New York, USA
(2) Division of Nutrition and Endocrinology, American Health Foundation, 10595 Valhalla, NY, USA

Received: 21 August 1995 Accepted: 27 October 1995

Diets rich in linoleic acid (LA) stimulate the metastasis of MDA-MB-435 human breast cancer cells from the mammary fat pads of nude mice. This omega-6 fatty acid is metabolized to various cyclo-oxygenase and lipoxygenase products, several of which have been previously associated with tumor cell invasion and metastasis. We now report that MDA-MB-435 cells secreted increased levels of prostaglandin E2 (PGE2),

06-14-2008, 03:31 PM	#245
R.B. Senior Member Join Date: Mar 2006 Posts: 1,843	More evidence Omega 6 LA is implicated in BC. And why COX blockers may have an impact as the block these pathways. And more PGE2 may = more aromatase = more oestrogen products More oestrogen would result in more conversion of LA to AA the raw material for this process be enhancing long chain fat conversion. SO this could be a self fuelling tumour loop where Omega 6 is present in excess and there is no Omega 3 to moderate the process. RB http://www.springerlink.com/content/n547j2538p317388/ Xin-Hua Liu1, Jeanne M. Connolly1 and David P. Rose1 Contact Information (1) Division of Nutrition and Endocrinology, American Health Foundation, Valhalla, New York, USA (2) Division of Nutrition and Endocrinology, American Health Foundation, 10595 Valhalla, NY, USA Received: 21 August 1995 Accepted: 27 October 1995 Diets rich in linoleic acid (LA) stimulate the metastasis of MDA-MB-435 human breast cancer cells from the mammary fat pads of nude mice. This omega-6 fatty acid is metabolized to various cyclo-oxygenase and lipoxygenase products, several of which have been previously associated with tumor cell invasion and metastasis. We now report that MDA-MB-435 cells secreted increased levels of prostaglandin E2 (PGE2), Last edited by R.B.; 06-14-2008 at 03:37 PM..