HER2 Support Group Forums - View Single Post - COX2 and BC a cumulative knowledge thread

R.B. · 11-05-2007, 06:43 PM

Gurpreet Singh-Ranger1, Mohamed Salhab1 and Kefah Mokbel1, 2 Contact Information
(1) St George’s University of London, London, UK
(2) The London Breast Institute, The Princess Grace Hospital, 42-52 Nottingham Place, London, W1M 3FD, UK

Received: 28 May 2007 Accepted: 1 June 2007 Published online: 12 July 2007

http://www.springerlink.com/content/8310235677lm7875/

"Abstract There is a growing body of evidence that COX-2 expression s a fundamental step in breast cancer pathogenesis acting through prostaglandin-dependent and independent mechanisms. Epidemiological studies suggest that NSAIDs confer a moderate degree of benefit against breast cancer. However further work is required to establish how this enzyme system can be best manipulated for therapeutic benefit."

11-05-2007, 06:43 PM	#12
R.B. Senior Member Join Date: Mar 2006 Posts: 1,843	Gurpreet Singh-Ranger1, Mohamed Salhab1 and Kefah Mokbel1, 2 Contact Information (1) St George’s University of London, London, UK (2) The London Breast Institute, The Princess Grace Hospital, 42-52 Nottingham Place, London, W1M 3FD, UK Received: 28 May 2007 Accepted: 1 June 2007 Published online: 12 July 2007 http://www.springerlink.com/content/8310235677lm7875/ "Abstract There is a growing body of evidence that COX-2 expression s a fundamental step in breast cancer pathogenesis acting through prostaglandin-dependent and independent mechanisms. Epidemiological studies suggest that NSAIDs confer a moderate degree of benefit against breast cancer. However further work is required to establish how this enzyme system can be best manipulated for therapeutic benefit."