HER2 Support Group Forums - View Single Post - Genetic step leading to her2 breast cancer development found

Emmay · 04-04-2006, 08:43 AM

Dexamethasone is Decadron. These articles (the first one from Christine MH-UK and the immediately previous one from unregistered guest sent on 3/28 at 7:17) are so technical, I'm not sure if I'm understanding them, but does it sound like Decadron might be a problem for people with Her2+ bc? As most of us are aware, the incidence of brain mets is notable for women on Herceptin, which can often keep most of the body clear but does not cross the blood/brain barrier. Decadron is usually prescribed for women being treated for brain mets (by craniotomy or any of the radiation options) to control the swelling -- do these articles suggest that while the Decadron may be controling swelling in the brain, it may also be enabling/fortifying the AP2-alpha protein and therefore the Her2 cancer cells as well? Please can someone tell me I'm all wrong? - I hope so. I'm about as far from a biochemistry major as a person could be, but I'm trying hard to understand this.

04-04-2006, 08:43 AM	#8
Emmay Senior Member Join Date: Apr 2006 Location: Boston Posts: 66	Ap2 and Decadron - biochem problem for Her2+ bc? Dexamethasone is Decadron. These articles (the first one from Christine MH-UK and the immediately previous one from unregistered guest sent on 3/28 at 7:17) are so technical, I'm not sure if I'm understanding them, but does it sound like Decadron might be a problem for people with Her2+ bc? As most of us are aware, the incidence of brain mets is notable for women on Herceptin, which can often keep most of the body clear but does not cross the blood/brain barrier. Decadron is usually prescribed for women being treated for brain mets (by craniotomy or any of the radiation options) to control the swelling -- do these articles suggest that while the Decadron may be controling swelling in the brain, it may also be enabling/fortifying the AP2-alpha protein and therefore the Her2 cancer cells as well? Please can someone tell me I'm all wrong? - I hope so. I'm about as far from a biochemistry major as a person could be, but I'm trying hard to understand this.