HER2 Support Group Forums - View Single Post - Circadian Rhythm, eating schedule etc and treatment

Rich66 · 12-04-2009, 01:39 PM

Vol. 301 No. 9, March 4, 2009
Timing Chemotherapy
Bridget M. Kuehn JAMA. 2009;301(9):924.
Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.
Scientists have found a biological mechanism that may explain why chemotherapy is more effective when given at certain times of the day. Previous evidence had suggested the circadian clock plays a role. In the current study, researchers from the University of North Carolina in Chapel Hill demonstrated how a specific DNA-repair mechanism regulated by the clock may explain the phenomenon (Kang T et al. Proc Natl Acad Sci U S A. 10.1073/pnas.0812638106 [published online ahead of print January 21, 2009]). The researchers measured the activity at various times of day of the nucleotide excision repair system in tissue from the mouse cortex. They found the system is most active in the afternoon and evening hours and least active in the morning. This may explain why chemotherapy is more effective in the morning because this system is less able to repair DNA damage in cancer cells. Because . . . [Full Text of this Article]

12-04-2009, 01:39 PM	#11
Rich66 Senior Member Join Date: Feb 2008 Location: South East Wisconsin Posts: 3,431	Re: Circadian Rhythm, eating schedule etc and treatment Vol. 301 No. 9, March 4, 2009 Timing Chemotherapy Bridget M. Kuehn JAMA. 2009;301(9):924. Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. Scientists have found a biological mechanism that may explain why chemotherapy is more effective when given at certain times of the day. Previous evidence had suggested the circadian clock plays a role. In the current study, researchers from the University of North Carolina in Chapel Hill demonstrated how a specific DNA-repair mechanism regulated by the clock may explain the phenomenon (Kang T et al. Proc Natl Acad Sci U S A. 10.1073/pnas.0812638106 [published online ahead of print January 21, 2009]). The researchers measured the activity at various times of day of the nucleotide excision repair system in tissue from the mouse cortex. They found the system is most active in the afternoon and evening hours and least active in the morning. This may explain why chemotherapy is more effective in the morning because this system is less able to repair DNA damage in cancer cells. Because . . . [Full Text of this Article] __________________ Mom's treatment history (link)