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Rich66 · 10-27-2009, 01:52 PM

2002, Vol. 19, No. 1, Pages 21-41
Tumor-based rhythms of anticancer efficacy in experimental models

Teresa G. Granda

*¹ and Francis Lévi

*² ¹Hôpital Paul Brousse, INSERM EPI 0118 “Cancer Chronotherapeutics,” Université Paris XI, 14–16 Avenue Paul-Vaillant Couturier, Villejuif, 94800, France
²Hôpital Paul Brousse, INSERM EPI 0118 “Cancer Chronotherapeutics,” Université Paris XI, 14–16 Avenue Paul-Vaillant Couturier, Villejuif, 94800, France

Experimental tumor models constitute a prerequisite toward chronotherapy testing in cancer patients. Studies in experimental models are required to understand the relation between tumor rhythms and antitumor treatments efficacy. In healthy tissues, cell proliferation, and differentiation processes are regulated precisely and exhibit marked circadian rhythmicity. Experimental and human tumors can retain circadian rhythms or display altered oscillations. Healthy tissues can also display rhythm modifications, possibly related to cancer stage. Cellular rhythms modulate the metabolism of cytotoxic agents and the cellular response to them; hence, they determine the chronopharmacology of anticancer drugs. Circadian rhythms in host tolerability and/or cancer chemotherapy efficacy have been demonstrated with nontoxic doses of drugs in several experimental tumor models, while in other ones a circadian-time effect was only seen within a specific dose range. The usual coupling between tolerability and efficacy rhythms of anticancer agents has resulted in significant improvement of their therapeutic index. Results of laboratory animal studies have been extrapolated to the design of clinical cancer therapy trials involving a chronobiological approach.

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10-27-2009, 01:52 PM	#5
Rich66 Senior Member Join Date: Feb 2008 Location: South East Wisconsin Posts: 3,431	Re: Circadian Rhythm, eating schedule etc and treatment 2002, Vol. 19, No. 1, Pages 21-41 Tumor-based rhythms of anticancer efficacy in experimental models Teresa G. Granda¹ and Francis Lévi² ¹Hôpital Paul Brousse, INSERM EPI 0118 “Cancer Chronotherapeutics,” Université Paris XI, 14–16 Avenue Paul-Vaillant Couturier, Villejuif, 94800, France ²Hôpital Paul Brousse, INSERM EPI 0118 “Cancer Chronotherapeutics,” Université Paris XI, 14–16 Avenue Paul-Vaillant Couturier, Villejuif, 94800, France Experimental tumor models constitute a prerequisite toward chronotherapy testing in cancer patients. Studies in experimental models are required to understand the relation between tumor rhythms and antitumor treatments efficacy. In healthy tissues, cell proliferation, and differentiation processes are regulated precisely and exhibit marked circadian rhythmicity. Experimental and human tumors can retain circadian rhythms or display altered oscillations. Healthy tissues can also display rhythm modifications, possibly related to cancer stage. Cellular rhythms modulate the metabolism of cytotoxic agents and the cellular response to them; hence, they determine the chronopharmacology of anticancer drugs. Circadian rhythms in host tolerability and/or cancer chemotherapy efficacy have been demonstrated with nontoxic doses of drugs in several experimental tumor models, while in other ones a circadian-time effect was only seen within a specific dose range. The usual coupling between tolerability and efficacy rhythms of anticancer agents has resulted in significant improvement of their therapeutic index. Results of laboratory animal studies have been extrapolated to the design of clinical cancer therapy trials involving a chronobiological approach. Full Text \| PDF (123 KB) \| PDF Plus (130 KB) __________________ Mom's treatment history (link)