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Old 06-28-2009, 11:58 AM   #2
chrisy
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Join Date: Sep 2005
Location: Central Coast, CA
Posts: 3,207
I do not know the specific stats on Tykerb vs Herceptin effect on the heart, if there are any.

I do know that when I was on Tykerb I continued to have my LVEF monitored but it seemed that my "numbers" were better than when on Herceptin. So that's my one person statistic

Since Her2 is also expressed in cardiac tissue, they do want to monitor your heart health whenever targeting Her2 - being cancer-free won't do us much good without beating hearts...

Hope you do well on the Tykerb/Xeloda. Make sure you check out the side effect recommendations (hutchibk's got the master post on this!). Most people find the side effects manageable, but some have needed dosage adjustments.

Hang in there,
chris
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Chris in Scotts Valley
June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial

5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure
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