HER2 Support Group Forums - View Single Post - Has anyone been on TDM-1 for more than 2 years?

phil · 02-19-2014, 06:11 PM

just an fyi to those on t dm-1 one yr plus. Lorraine has developed some varices ( varicose veins) around liver, spleen . some blood not getting thru . had biopsy and preliminary report is its a smaller issue , Thank God. biopsy says no cirrhosis, and good outflow pressure from liver. from t dm-1's chronic liver irritation .so we reduced dose again , to 2.7. liver varices developed sometime in early yr 2. small, not spotted until a few months ago , at end of yr 3 . now 3 months into yr 4 . if u have been on drug long term and have high lfts, alt/ast counts up to 100 or so. lorraines' liver counts would go down when given extra time betw. doses so we didn't worry , until now. share this info w/ your doc.

02-19-2014, 06:11 PM	#17
phil Senior Member Join Date: Nov 2010 Posts: 393	Re: Has anyone been on TDM-1 for more than 2 years? just an fyi to those on t dm-1 one yr plus. Lorraine has developed some varices ( varicose veins) around liver, spleen . some blood not getting thru . had biopsy and preliminary report is its a smaller issue , Thank God. biopsy says no cirrhosis, and good outflow pressure from liver. from t dm-1's chronic liver irritation .so we reduced dose again , to 2.7. liver varices developed sometime in early yr 2. small, not spotted until a few months ago , at end of yr 3 . now 3 months into yr 4 . if u have been on drug long term and have high lfts, alt/ast counts up to 100 or so. lorraines' liver counts would go down when given extra time betw. doses so we didn't worry , until now. share this info w/ your doc.