HER2 Support Group Forums - View Single Post - Due For Mammo, But Thinking About Prophylatic Masectomy

Becky · 09-18-2008, 07:44 AM

http://www.medicine.ox.ac.uk/bandoli...07/b107-2.html

http://health.discovery.com/centers/...astectomy.html

http://clinicalevidence.bmj.com/cewe...2/0102_I19.jsp

Attached are various studies and an interview with Susan Love on the effectiveness of local recurrence for masectomy (radical) vs lumpectomy with and without radiation. There is a 10 yr comparison and a 20yr follow up comparison with NO difference between the two and the rate is low 5% - 10%.

However, I will make a personal comment that I am sure masectomy is more beneficial in CERTAIN cases - large tumor or lots of nodes. Perhaps a woman might be recommended masectomy on those terms and refuses so she takes neoadjuvant chemo to shrink the tumor and reduce the nodes and perhaps the local recurrence risk is greater in THAT case. These attached studies include overall survival and distant recurrence rates between the 2 surgeries too. All good for either procedure. Susan Love's interview is good too and she makes a comment about propholactic masectomy (of the unaffected side too - she recommends it for BRCA+ but not overall).

Cheers!

09-18-2008, 07:44 AM	#16
Becky Senior Member Join Date: Sep 2005 Location: Stockton, NJ Posts: 4,179	http://www.medicine.ox.ac.uk/bandoli...07/b107-2.html http://health.discovery.com/centers/...astectomy.html http://clinicalevidence.bmj.com/cewe...2/0102_I19.jsp Attached are various studies and an interview with Susan Love on the effectiveness of local recurrence for masectomy (radical) vs lumpectomy with and without radiation. There is a 10 yr comparison and a 20yr follow up comparison with NO difference between the two and the rate is low 5% - 10%. However, I will make a personal comment that I am sure masectomy is more beneficial in CERTAIN cases - large tumor or lots of nodes. Perhaps a woman might be recommended masectomy on those terms and refuses so she takes neoadjuvant chemo to shrink the tumor and reduce the nodes and perhaps the local recurrence risk is greater in THAT case. These attached studies include overall survival and distant recurrence rates between the 2 surgeries too. All good for either procedure. Susan Love's interview is good too and she makes a comment about propholactic masectomy (of the unaffected side too - she recommends it for BRCA+ but not overall). Cheers! __________________ Kind regards Becky Found lump via BSE Diagnosed 8/04 at age 45 1.9cm tumor, ER+PR-, Her2 3+(rt side) 2 micromets to sentinel node Stage 2A left 3mm DCIS - low grade ER+PR+Her2 neg lumpectomies 9/7/04 4DD AC followed by 4 DD taxol Used Leukine instead of Neulasta 35 rads on right side only 4/05 started Tamoxifen Started Herceptin 4 months after last Taxol due to trial results and 2005 ASCO meeting & recommendations Oophorectomy 8/05 Started Arimidex 9/05 Finished Herceptin (16 months) 9/06 Arimidex Only Prolia every 6 months for osteopenia NED 18 years! Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"