HER2 Support Group Forums - View Single Post - Ipilimumab: controversies in its development, utility and autoimmune adverse events

Rich66 · 06-21-2009, 12:27 PM

http://www.springerlink.com/content/...1/fulltext.pdf

An interesting introduction to a drug making big waves right now in prostate cancer.
http://www.minnpost.com/healthblog/2...e_cancer_study

There was a stage IV BC trial but I can't find results.
http://clinicaltrials.gov/show/NCT00083278

Anyway..
I found the focus on side effects as early signal of benefit and possibility that traditional measures of efficacy may prematurely deem drugs like this a failure before they gather steam. The paper suggests response rate is almost doubled when given proper length of trial.
More here: http://www.cancerresearch.org/Programs.aspx?id=2340
Yes...me thinks it ties into cancer stem cells and the issues of judging success.

06-21-2009, 12:27 PM	#1
Rich66 Senior Member Join Date: Feb 2008 Location: South East Wisconsin Posts: 3,431	Ipilimumab: controversies in its development, utility and autoimmune adverse events http://www.springerlink.com/content/...1/fulltext.pdf An interesting introduction to a drug making big waves right now in prostate cancer. http://www.minnpost.com/healthblog/2...e_cancer_study There was a stage IV BC trial but I can't find results. http://clinicaltrials.gov/show/NCT00083278 Anyway.. I found the focus on side effects as early signal of benefit and possibility that traditional measures of efficacy may prematurely deem drugs like this a failure before they gather steam. The paper suggests response rate is almost doubled when given proper length of trial. More here: http://www.cancerresearch.org/Programs.aspx?id=2340 Yes...me thinks it ties into cancer stem cells and the issues of judging success.