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michka · 05-21-2016, 03:02 AM

Hello to you all.
I have not posted much these last 2 or 3 months because the stupid cancer came back in my liver. TDM1/Kadcyla saved me 4 years ago. I became Ned in 4 rounds. I took it 3 years and stopped 14 months but numerous tumors came back in my liver. The largest ones were 2 cm. I decided with my onc to go back on Kadcyla hoping it would work again.
I had 2 rounds and went for a MRI. The news is very encouraging since many tumors are not visible anymore and the large ones shrunk by 40%. It gives me courage to continue. The first round was at the highest dosage and it was hell for me. I did not know if I would be able to go further. My onc lowered the dosage 2 notches for the second round and it was better even if it is still difficult. Nobody understands why I have so many side effects when most women can take Kadcyla with mild problems. Kadcyla was always difficult for me but it saved me so I am hoping it will save me once more.
Next round on Monday. I dread going but have no other choice. I would like to get back to Ned and hold out another 4 years hoping our oncs will come out with something new.
Love to all.

05-21-2016, 03:02 AM	#1
michka Senior Member Join Date: Feb 2007 Location: Paris, France Posts: 858	News. Back on Kadcyla Hello to you all. I have not posted much these last 2 or 3 months because the stupid cancer came back in my liver. TDM1/Kadcyla saved me 4 years ago. I became Ned in 4 rounds. I took it 3 years and stopped 14 months but numerous tumors came back in my liver. The largest ones were 2 cm. I decided with my onc to go back on Kadcyla hoping it would work again. I had 2 rounds and went for a MRI. The news is very encouraging since many tumors are not visible anymore and the large ones shrunk by 40%. It gives me courage to continue. The first round was at the highest dosage and it was hell for me. I did not know if I would be able to go further. My onc lowered the dosage 2 notches for the second round and it was better even if it is still difficult. Nobody understands why I have so many side effects when most women can take Kadcyla with mild problems. Kadcyla was always difficult for me but it saved me so I am hoping it will save me once more. Next round on Monday. I dread going but have no other choice. I would like to get back to Ned and hold out another 4 years hoping our oncs will come out with something new. Love to all. __________________ 08.2006 3 cm IDC Stage 2-3, HER2 3+ ER+90% PR 20% FEC, Taxol+ Herceptin, Mastectomy, Radiation, Herceptin 1 year followed by Tykerb 1 year,Aromasin /Faslodex 12.2010 Mets to liver,Herceptin+Tykerb 03.2011 Liver resection ER+70% PR- 04.2011 Herceptin+Navelbine+750mg Tykerb 06.2011 Liver ned, Met to sternum. Added Zometa 09.2011 Cyberknife for sternum 11.2011 Pet clear. Stop Navelbine, continuing on Hercpetin+Tykerb+Aromasin 02.2012 Mets to lungs, nodes, liver 04.2012 TDM1, Ned in 07.2012 04.2015 Stop TDM1/Kadcyla, still Ned, liver problems 04.2016 Liver mets. Back on Kadcyla 08.2016 Kadcyla stopped working. mets to liver lungs bones 09.2016 Biopsy to liver. no more HER2, still ER+ 09.2016 CMF Afinitor/Aromasin/ Xgeva.Met to eye muscle Cyberknife 01.2017 Gemzar/Carboplatin/ Ibrance/Faslodex then Taxotere 02.2017 30 micro mets to brain breathing getting worse and worse 04.2017 Liquid biopsy/CTC indicates HER2 again. Start Herceptin with Halaven 06.2017 all tumors shrunk 60% . more micro mets to brain (1mm mets) no symptoms