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R.B. · 10-26-2013, 03:15 AM

Perchlorate intake in rats leads to alteration in breast tissue

and earlier breast developmental issues. Yes they are using large amounts but it still demonstrates that iodine uptake is essential to breast health, and perchlorate is a blocker of iodine uptake in the breast so a risk exists from perchlorate we put into the environment, and especially so when combined with the issues of additional blocking fluoride chlorination nitrates food goitrogens etc

Arch Pathol Lab Med. 1979 Nov;103(12):631-4.
Age-related changes resembling fibrocystic disease in iodine-blocked rat breasts.
Krouse TB, Eskin BA, Mobini J.
Abstract

It has been reported that dietary restriction and chemical blockade of iodine causes histopathologic changes in peripubertal female rat breasts. This study extended the age range to include midreproductive life and perimenopausal rats; there is a wider spectrum of structural alterations that are associated with the older breast, with sodium perchlorate as the blocking agent. In 16-week-old rats, breasts showed general increased parenchymal activity and growth, regressing after removal of the block. In 42-week-old rats, breasts showed noticeable calcospherite deposition, intralobular fibrosis, and cystic changes resembling human fibrocystic disease. In 52-week-old rats, breasts exhibited atypical lobules cytologically, papillomatosis, sclerosing adenosis, calcifications, and a lobular transformation of a histologically dysplastic type. It is the older rat that experiments will more closely parallel the human condition.

http://www.ncbi.nlm.nih.gov/pubmed/167953

Cancer Res. 1975 Sep;35(9):2332-9.
Rat mammary gland atypia produced by iodine blockade with perchlorate.
Eskin BA, Shuman R, Krouse T, Merion JA.
Abstract

Prior published work from our laboratory concluded that there was a need for appropriate metabolic activity of iodine in breast tissue for normal growth and development. Results from studies in rats that were made iodine deficient showed histological changes in the breasts that were atypical and dysplastic. These tissue findings were further affected by the presence of estrogen and thyroxine. These changes parallel the iodine uptake of the tissues, thus representing a difference in the utilization of iodine by the mammary glands. Using an ion blockade agent, sodium perchlorate, breast tissues lacking iodine were evaluated by both endocrine and histological techniques. A dose-response series was completed that showed that perchlorate therapy for 8 weeks at 400 mg/100 ml produced breast blockade by a reduction in iodine uptake of greater than 52% of the control. At these levels, the histological experimentation showed atypia and some pleomorphism of the cells, particularly in the glands of the lobules. Blockade was less effective in estrogen-treated groups. It is especially notable that both histological changes and uptake reduction were greatest in those breasts that had been rendered euthyroid by thyroxine replacement, thus clearly indicating the necessity of iodine itself for maintenance of normal breast development. By this blockade the responses of iodine inadequacy in the breast were shown to cause abnormal tissue changes relative to the percentage of the block obtained.

10-26-2013, 03:15 AM	#38
R.B. Senior Member Join Date: Mar 2006 Posts: 1,843	Re: Iodine deficiency ! - falling intakes - goitregens - competition bromine and fluo Perchlorate intake in rats leads to alteration in breast tissue and earlier breast developmental issues. Yes they are using large amounts but it still demonstrates that iodine uptake is essential to breast health, and perchlorate is a blocker of iodine uptake in the breast so a risk exists from perchlorate we put into the environment, and especially so when combined with the issues of additional blocking fluoride chlorination nitrates food goitrogens etc Arch Pathol Lab Med. 1979 Nov;103(12):631-4. Age-related changes resembling fibrocystic disease in iodine-blocked rat breasts. Krouse TB, Eskin BA, Mobini J. Abstract It has been reported that dietary restriction and chemical blockade of iodine causes histopathologic changes in peripubertal female rat breasts. This study extended the age range to include midreproductive life and perimenopausal rats; there is a wider spectrum of structural alterations that are associated with the older breast, with sodium perchlorate as the blocking agent. In 16-week-old rats, breasts showed general increased parenchymal activity and growth, regressing after removal of the block. In 42-week-old rats, breasts showed noticeable calcospherite deposition, intralobular fibrosis, and cystic changes resembling human fibrocystic disease. In 52-week-old rats, breasts exhibited atypical lobules cytologically, papillomatosis, sclerosing adenosis, calcifications, and a lobular transformation of a histologically dysplastic type. It is the older rat that experiments will more closely parallel the human condition. http://www.ncbi.nlm.nih.gov/pubmed/167953 Cancer Res. 1975 Sep;35(9):2332-9. Rat mammary gland atypia produced by iodine blockade with perchlorate. Eskin BA, Shuman R, Krouse T, Merion JA. Abstract Prior published work from our laboratory concluded that there was a need for appropriate metabolic activity of iodine in breast tissue for normal growth and development. Results from studies in rats that were made iodine deficient showed histological changes in the breasts that were atypical and dysplastic. These tissue findings were further affected by the presence of estrogen and thyroxine. These changes parallel the iodine uptake of the tissues, thus representing a difference in the utilization of iodine by the mammary glands. Using an ion blockade agent, sodium perchlorate, breast tissues lacking iodine were evaluated by both endocrine and histological techniques. A dose-response series was completed that showed that perchlorate therapy for 8 weeks at 400 mg/100 ml produced breast blockade by a reduction in iodine uptake of greater than 52% of the control. At these levels, the histological experimentation showed atypia and some pleomorphism of the cells, particularly in the glands of the lobules. Blockade was less effective in estrogen-treated groups. It is especially notable that both histological changes and uptake reduction were greatest in those breasts that had been rendered euthyroid by thyroxine replacement, thus clearly indicating the necessity of iodine itself for maintenance of normal breast development. By this blockade the responses of iodine inadequacy in the breast were shown to cause abnormal tissue changes relative to the percentage of the block obtained. Last edited by R.B.; 10-26-2013 at 03:27 AM..