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jane2638 · 01-09-2012, 07:41 AM

Hi Alli,

My impression is that her2+ is more likely to be resistant to Tamox than her2-. I've also seen the opinion that inducing menopause yields better outcomes. However, AIs have not been approved for premenopausal women in the U.S. I guess this means that if you want an alternative to Tamox, you either have an oophorectomy straight out, which seems pretty brutal, or use an LHRH agonist, then have an oophorectomy, then go to an AI. I think an LHRH agonist can also be combined with Tamox. I'm still grilling my onc about all this.

Cheers,
Jane

01-09-2012, 07:41 AM	#26
jane2638 Member Join Date: Oct 2011 Posts: 19	Re: Tamoxifen anxiety Hi Alli, My impression is that her2+ is more likely to be resistant to Tamox than her2-. I've also seen the opinion that inducing menopause yields better outcomes. However, AIs have not been approved for premenopausal women in the U.S. I guess this means that if you want an alternative to Tamox, you either have an oophorectomy straight out, which seems pretty brutal, or use an LHRH agonist, then have an oophorectomy, then go to an AI. I think an LHRH agonist can also be combined with Tamox. I'm still grilling my onc about all this. Cheers, Jane