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DianneS · 07-11-2009, 11:36 AM

Hi all,

I would like to hear from those of you who are taking AI's and are weakly ER+ . I understand this is not common and most folks are strongly ER and PR+.
Nevertheless my onc has me on Arimidex. In Canada we are not given % but only rated ER+1,+2 or +3. I am a +1 and I don't know how that translates into percentages.

Problem is....there is no real clear proof that AI's will help me and I don't want to ruin my bones for nothing. Sure, I can take Fosamex or something but one drug usually leads to taking another one and I would like to avoid that!

Any studies done on weakly ER+ and AI's? Any studies showing relatively long term effects, say 10-15 years after AI's and weakly er+?

Mucho thanks
Diannes

07-11-2009, 11:36 AM	#1
DianneS Senior Member Join Date: Aug 2008 Posts: 327	Aromatase Inhibitors/Weakly ER + Hi all, I would like to hear from those of you who are taking AI's and are weakly ER+ . I understand this is not common and most folks are strongly ER and PR+. Nevertheless my onc has me on Arimidex. In Canada we are not given % but only rated ER+1,+2 or +3. I am a +1 and I don't know how that translates into percentages. Problem is....there is no real clear proof that AI's will help me and I don't want to ruin my bones for nothing. Sure, I can take Fosamex or something but one drug usually leads to taking another one and I would like to avoid that! Any studies done on weakly ER+ and AI's? Any studies showing relatively long term effects, say 10-15 years after AI's and weakly er+? Mucho thanks Diannes __________________ Three years and 5 months NED Dx: Aug 2008 right breast IDC with 50% of tumor DCIS, Stage II or IIA, tumor size: 2.1 cm Grade 3 8/9 Richardson/Bloom test ER+ weakly positive Alred Score: 4 (suggesting I would strongly benefit from hormone therapy) PR-, HER2 positive +++ No vascular invasion No lymph nodes involved Surgery: Sept. 9, 2008 -Modified radical mastectomy, right breast. I chose to have a simple mastectomy on the left. Began Taxotere/Carboplatin/Herceptin November, 2008. Finished T/C March 2009. Finished #16 Herceptin Sept. 09. AI's and Tamoxifen made me sick. Began natural Tamoxifen which is Quercetin, I3C and a combo of other supplements. I am also a DES Daughter. There is now a link between DES exposure in utero and breast cancer!