HER2 Support Group Forums - View Single Post - Listen up bitches and queens (sorry!) cox2 associated with breast cancer in dogs,cats

Lani · 07-26-2006, 02:14 PM

it is one of three ENZYMES utilized to convert other hormones/precursors (DHEA, testosterone, etc) into estrogen and these hormones/precursors are particularly important in post-menopausal women where they are the primary source of estrogen. More pertinently breast cancer cells seem to make their own estrogen and these three enzymes seem to be intimately involved in that. AIs seem to inhibit aromatase (there are several generations of these and some are steroidal and some nonsteroidal), tibolone seems to inhibit one or two of the others. It is all FAR FROM COMPLETELY UNDERSTOOD and news of more intricacies regarding this emerge all the time.

NSAIDs seem to have aromatase inhibitor properties as well as antiangiogenic properties and it seems cox2 is UP TO NO GOOD IN MANY WAYS in breast cancer.

Hope this helps

07-26-2006, 02:14 PM	#4
Lani Senior Member Join Date: Mar 2006 Posts: 4,778	Sorry, but aromatase is not an estrogen precursor it is one of three ENZYMES utilized to convert other hormones/precursors (DHEA, testosterone, etc) into estrogen and these hormones/precursors are particularly important in post-menopausal women where they are the primary source of estrogen. More pertinently breast cancer cells seem to make their own estrogen and these three enzymes seem to be intimately involved in that. AIs seem to inhibit aromatase (there are several generations of these and some are steroidal and some nonsteroidal), tibolone seems to inhibit one or two of the others. It is all FAR FROM COMPLETELY UNDERSTOOD and news of more intricacies regarding this emerge all the time. NSAIDs seem to have aromatase inhibitor properties as well as antiangiogenic properties and it seems cox2 is UP TO NO GOOD IN MANY WAYS in breast cancer. Hope this helps