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R.B. · 07-26-2006, 03:47 AM

More links between repoduction and prostaglandins. " Although the mechanism by which prostaglandins modulate these changes remains unclear, much evidence suggests that prostaglandins and their receptors and downstream signalling pathways are involved in angiogenesis and in alterations in cell adhesion, morphology, motility, invasion and metastases. "

Whilst omega threes and GLA both produce separte series of prosaglandins series 1 and series 3 the limited materila I have read links 1 and 3 to moderating roles in cell maturation etc, and series 2 which are derived from omega six and AA are the drivers.

More questions

RB

http://www.ncbi.nlm.nih.gov/entrez/q..._uids=15380812

1: Trends Endocrinol Metab. 2004 Oct;15(8):398-404.Click here to read Links
Prostaglandin receptor signalling and function in human endometrial pathology.

* Jabbour HN,
* Sales KJ.

MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The University of Edinburgh Academic Centre, 49 Little France Crescent, Edinburgh EH16 4SB, Scotland, UK. h.jabbour@hrsu.mrc.ac.uk

Prostaglandins are bioactive lipids that exert an autocrine or paracrine function by binding to specific G-protein-coupled receptors (GPCRs) to activate intracellular signalling and gene transcription. Prostaglandins are key regulators of reproductive processes, including ovulation, implantation and menstruation. Prostaglandins have been ascertained to have a role in various pathological changes of the reproductive tract including menorrhagia, dysmenorrhea, endometriosis and cancer. Although the mechanism by which prostaglandins modulate these changes remains unclear, much evidence suggests that prostaglandins and their receptors and downstream signalling pathways are involved in angiogenesis and in alterations in cell adhesion, morphology, motility, invasion and metastases. The potential role of prostaglandin receptors in pathological changes of the endometrium has significance for the future development of therapeutic interventions.

PMID: 15380812 [PubMed - indexed for MEDLINE]

07-26-2006, 03:47 AM	#11
R.B. Senior Member Join Date: Mar 2006 Posts: 1,843	More links between repoduction and prostaglandins. " Although the mechanism by which prostaglandins modulate these changes remains unclear, much evidence suggests that prostaglandins and their receptors and downstream signalling pathways are involved in angiogenesis and in alterations in cell adhesion, morphology, motility, invasion and metastases. " Whilst omega threes and GLA both produce separte series of prosaglandins series 1 and series 3 the limited materila I have read links 1 and 3 to moderating roles in cell maturation etc, and series 2 which are derived from omega six and AA are the drivers. More questions RB http://www.ncbi.nlm.nih.gov/entrez/q..._uids=15380812 1: Trends Endocrinol Metab. 2004 Oct;15(8):398-404.Click here to read Links Prostaglandin receptor signalling and function in human endometrial pathology. * Jabbour HN, * Sales KJ. MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The University of Edinburgh Academic Centre, 49 Little France Crescent, Edinburgh EH16 4SB, Scotland, UK. h.jabbour@hrsu.mrc.ac.uk Prostaglandins are bioactive lipids that exert an autocrine or paracrine function by binding to specific G-protein-coupled receptors (GPCRs) to activate intracellular signalling and gene transcription. Prostaglandins are key regulators of reproductive processes, including ovulation, implantation and menstruation. Prostaglandins have been ascertained to have a role in various pathological changes of the reproductive tract including menorrhagia, dysmenorrhea, endometriosis and cancer. Although the mechanism by which prostaglandins modulate these changes remains unclear, much evidence suggests that prostaglandins and their receptors and downstream signalling pathways are involved in angiogenesis and in alterations in cell adhesion, morphology, motility, invasion and metastases. The potential role of prostaglandin receptors in pathological changes of the endometrium has significance for the future development of therapeutic interventions. PMID: 15380812 [PubMed - indexed for MEDLINE]