My oncologist says he feels the weekly is more balanced and works better as well as easier on the heart. He did say if I wanted to go every 3 weeks he would be o.k. with it or if I had to travel a long way to get to the clinic . He did not mention any studies to back up what he told me and usually he will say, "according to such and such study its this way". I opt to stay weekly because its not that inconvenient for me to go in every Friday morning. hugs. Sandy
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