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Lani · 07-15-2006, 05:07 AM

It discusses how tumors (and in this case her2 breast cancer) when faced with lack of oxygen because they overgrow their blood supply change their metabolism to "burn" glucose for energy without oxygen instead of with oxygen. The article discusses that reactive oxygen species/antioxidants
might actually select for those cells which don't need oxygen and encourage growth of those cancer cells which don't need oxygen to utilize glucose and grow. Another "wrinkle" in the dilemna of what to do!

Here is the info on the study. The full article is in my opinion a milestone
in thinking about how to treat cancer--

Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance

Valeria R. Fantin1, 3, 4, Julie St-Pierre2, 3, 5 and Philip Leder1, ,

1Department of Genetics, Harvard Medical School and Howard Hughes Medical Institute, Boston, Massachusetts 02115
2Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115

Received 21 November 2005; revised 27 February 2006; accepted 24 April 2006. Published: June 12, 2006. Available online 12 June 2006.

Referred to by: Cancer's sweet tooth, Cancer Cell, Volume 9, Issue 6, 13 June 2006, Pages 419-420
Thi Bui1 and Craig B. Thompson1, ,
SummaryPlus | Full Text + Links | PDF (202 K)

07-15-2006, 05:07 AM	#5
Lani Senior Member Join Date: Mar 2006 Posts: 4,778	The same authors are responsible for the Harvard study I quoted as so groundbreaking It discusses how tumors (and in this case her2 breast cancer) when faced with lack of oxygen because they overgrow their blood supply change their metabolism to "burn" glucose for energy without oxygen instead of with oxygen. The article discusses that reactive oxygen species/antioxidants might actually select for those cells which don't need oxygen and encourage growth of those cancer cells which don't need oxygen to utilize glucose and grow. Another "wrinkle" in the dilemna of what to do! Here is the info on the study. The full article is in my opinion a milestone in thinking about how to treat cancer-- Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance Valeria R. Fantin1, 3, 4, Julie St-Pierre2, 3, 5 and Philip Leder1, , 1Department of Genetics, Harvard Medical School and Howard Hughes Medical Institute, Boston, Massachusetts 02115 2Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115 Received 21 November 2005; revised 27 February 2006; accepted 24 April 2006. Published: June 12, 2006. Available online 12 June 2006. Referred to by: Cancer's sweet tooth, Cancer Cell, Volume 9, Issue 6, 13 June 2006, Pages 419-420 Thi Bui1 and Craig B. Thompson1, , SummaryPlus \| Full Text + Links \| PDF (202 K)