HER2 Support Group Forums - View Single Post - lack herceptin response lowered with PI3K inhibitor...

RobinP · 07-14-2006, 06:34 PM

I'm glad the information has helped you. Sorry to hear that you have bone mets, others have stayed on Herceptin in such a situation, assuming that Herceptin still is helping. Of course, you don't know for sure you don't have pTEN and that you need a PI3K inhibitor unless you did have pTEN tested like some rare others here on this board. I think there may be other things that causes progression while on Herceptin too like high levels of her1,3 and posssibly IGFR. There is just so much that is unknown yet as to all the specific causes of progression while on Hercpetin and medication remedies for it. I do think at MD Anderson, Dr. Esteva and at Dana Farber's Cancer Center- Dr. Winer are studying progression while on Herceptin and may have more information.Good luck to you, you're in my prayers.

Becky mentioned a natural PI3K inhibitor months ago, I think it was Selenium and Maitake Mushrooms activate pTEN and turn it on. See that posting link...
http://her2support.org/vbulletin/sho...referrerid=454

07-14-2006, 06:34 PM	#5
RobinP Senior Member Join Date: Nov 2005 Posts: 943	I'm glad the information has helped you. Sorry to hear that you have bone mets, others have stayed on Herceptin in such a situation, assuming that Herceptin still is helping. Of course, you don't know for sure you don't have pTEN and that you need a PI3K inhibitor unless you did have pTEN tested like some rare others here on this board. I think there may be other things that causes progression while on Herceptin too like high levels of her1,3 and posssibly IGFR. There is just so much that is unknown yet as to all the specific causes of progression while on Hercpetin and medication remedies for it. I do think at MD Anderson, Dr. Esteva and at Dana Farber's Cancer Center- Dr. Winer are studying progression while on Herceptin and may have more information.Good luck to you, you're in my prayers. Becky mentioned a natural PI3K inhibitor months ago, I think it was Selenium and Maitake Mushrooms activate pTEN and turn it on. See that posting link... http://her2support.org/vbulletin/sho...referrerid=454 __________________ Robin 2002- dx her2 positive DCIS/bc TX Mast, herceptin chemo Last edited by RobinP; 07-14-2006 at 06:54 PM..