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I take a benedryl tablet myself before my every three week herceptin treatment. I have asthma. I also had anaphalaxic shock at age 20 from an allergic reaction to penicillan. After I was diagnosed I started reading up on Herceptin and became petrified when I read that you could get an allergic reaction. I read the reactions happen often to people who have mouse allergies, because the petrie dish where they grow the herceptin is lined with mouse embryos. So I asked my allergist to test me for mouse allergy. I tested negative. I told the oncologist and I got Herceptin without pre-meds. No problem except a mild cough. But for peace of mind, I take a benedryl before treatment.
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