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Please take this at face value as it emphasizes hormone positive bc. At ASCO, many of the posters and presentations focused on who chemo helps the most in an adjuvant setting. Chemo may not help women with early breast cancer that are only highly ER/PR positive. Even if there are 3 or less nodes involved. However, regardless of ER/PR status, if you are Her2 positive, chemo is of great benefit regardless of node status. It is also very beneficial to the triple negative women, regardless of node status.
The taxanes seem to be of absolutely no value if you are only hormone positive but it is of great value (after AC in these studies) if you are Her2+ (again - of great benefit if you are also hormone positive too - as long as you are also Her2) or triple negative. There were equal results of AC followed by taxol or taxotere.
Therefore, it is imperative that women who are hormone positive take hormone therapy AND if they are not strongly positive (but her2 negative), perhaps get their tumor tested for Her1 or get into a trial using Avastin in early stage or something like that (because they probably have something else going on as well).
This article is absolutely geared to the highly hormone positive women.
Kind regards
Becky
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