HER2 Support Group Forums - View Single Post - ANASTROZOLE+HERCEPTIN: possible justification

R.B. · 05-26-2006, 10:41 AM

IF DHA and oestrogen are linked in a two way rather than oestrogen only effecting DHA... Taking higher levels of DHA may well push down oestogen.

Oestrogen and DHA are both central to fertility.

IS DHA one of several internal body marker regulators of oestrogen levels?

Thanks for the interesting post.

RB

RB

1: Am J Clin Nutr. 2004 Nov;80(5):1167-74. Related Articles, Links
Click here to read
Docosahexaenoic acid concentrations are higher in women than in men because of estrogenic effects.

Giltay EJ, Gooren LJ, Toorians AW, Katan MB, Zock PL.

Psychiatric Center GGZ Delfland, Delft, Netherlands. giltay@dds.nl

BACKGROUND: During pregnancy there is a high demand for docosahexaenoic acid (DHA), which is needed for formation of the fetal brain. Women who do not consume marine foods must synthesize DHA from fatty acid precursors in vegetable foods. OBJECTIVE: We studied sex differences in DHA status and the role of sex hormones. DESIGN: First, DHA status was compared between 72 male and 103 female healthy volunteers who ate the same rigidly controlled diets. Second, the effects of sex hormones were studied in 56 male-to-female transsexual subjects, who were treated with cyproterone acetate alone or randomly assigned to receive oral ethinyl estradiol or transdermal 17beta-estradiol combined with cyproterone acetate, and in 61 female-to-male transsexual subjects, who were treated with testosterone esters or randomly assigned for treatment with the aromatase inhibitor anastrozole or placebo in addition to the testosterone regimen. RESULTS: The proportion of DHA was 15 +/- 4% (x +/- SEM; P < 0.0005) higher in the women than in the men. Among the women, those taking oral contraceptives had 10 +/- 4% (P = 0.08) higher DHA concentrations than did those not taking oral contraceptives. Administration of oral ethinyl estradiol, but not transdermal 17beta-estradiol, increased DHA by 42 +/- 8% (P < 0.0005), whereas the antiandrogen cyproterone acetate did not affect DHA. Parenteral testosterone decreased DHA by 22 +/- 4% (P < 0.0005) in female-to-male transsexual subjects. Anastrozole decreased estradiol concentrations significantly and DHA concentrations nonsignificantly (9 +/- 6%; P = 0.09). CONCLUSION: Estrogens cause higher DHA concentrations in women than in men, probably by upregulating synthesis of DHA from vegetable precursors.

Publication Types:

* Clinical Trial
* Randomized Controlled Trial

PMID: 15531662 [PubMed - indexed for MEDLINE]

05-26-2006, 10:41 AM	#2
R.B. Senior Member Join Date: Mar 2006 Posts: 1,843	IF DHA and oestrogen are linked in a two way rather than oestrogen only effecting DHA... Taking higher levels of DHA may well push down oestogen. Oestrogen and DHA are both central to fertility. IS DHA one of several internal body marker regulators of oestrogen levels? Thanks for the interesting post. RB RB 1: Am J Clin Nutr. 2004 Nov;80(5):1167-74. Related Articles, Links Click here to read Docosahexaenoic acid concentrations are higher in women than in men because of estrogenic effects. Giltay EJ, Gooren LJ, Toorians AW, Katan MB, Zock PL. Psychiatric Center GGZ Delfland, Delft, Netherlands. giltay@dds.nl BACKGROUND: During pregnancy there is a high demand for docosahexaenoic acid (DHA), which is needed for formation of the fetal brain. Women who do not consume marine foods must synthesize DHA from fatty acid precursors in vegetable foods. OBJECTIVE: We studied sex differences in DHA status and the role of sex hormones. DESIGN: First, DHA status was compared between 72 male and 103 female healthy volunteers who ate the same rigidly controlled diets. Second, the effects of sex hormones were studied in 56 male-to-female transsexual subjects, who were treated with cyproterone acetate alone or randomly assigned to receive oral ethinyl estradiol or transdermal 17beta-estradiol combined with cyproterone acetate, and in 61 female-to-male transsexual subjects, who were treated with testosterone esters or randomly assigned for treatment with the aromatase inhibitor anastrozole or placebo in addition to the testosterone regimen. RESULTS: The proportion of DHA was 15 +/- 4% (x +/- SEM; P < 0.0005) higher in the women than in the men. Among the women, those taking oral contraceptives had 10 +/- 4% (P = 0.08) higher DHA concentrations than did those not taking oral contraceptives. Administration of oral ethinyl estradiol, but not transdermal 17beta-estradiol, increased DHA by 42 +/- 8% (P < 0.0005), whereas the antiandrogen cyproterone acetate did not affect DHA. Parenteral testosterone decreased DHA by 22 +/- 4% (P < 0.0005) in female-to-male transsexual subjects. Anastrozole decreased estradiol concentrations significantly and DHA concentrations nonsignificantly (9 +/- 6%; P = 0.09). CONCLUSION: Estrogens cause higher DHA concentrations in women than in men, probably by upregulating synthesis of DHA from vegetable precursors. Publication Types: * Clinical Trial * Randomized Controlled Trial PMID: 15531662 [PubMed - indexed for MEDLINE]