HER2 Support Group Forums - View Single Post - a drug already approved found to make chemotherapy more effectve&protects normalcells

Lani · 05-21-2006, 09:38 AM

can only find molecular weight (770) not size but read it is a chelated metal which normally are too big to diffuse out of the circulation much and therefore end up in the liver for processing. Seems rather unlikely (even though I could not find the molecular size so far) that it would cross the blood-brain barrier (molecules <500 Daltons can do so reliably IF they meet other characteristics regarding their shape, lipophilicity (literally love/like of fat, practically how well it mixes with fat --think of oil and vinegar salad dressing!) Haven't reallyhad to use my biochemistry-course gained knowledge of molecular size,weight and lipophobic/lipophilic properties for 30 years--amazing some of it is still in the old lipophylic brain! (I am sure RB has something to say about that)

Hope some of this helped...

05-21-2006, 09:38 AM	#4
Lani Senior Member Join Date: Mar 2006 Posts: 4,778	and more... can only find molecular weight (770) not size but read it is a chelated metal which normally are too big to diffuse out of the circulation much and therefore end up in the liver for processing. Seems rather unlikely (even though I could not find the molecular size so far) that it would cross the blood-brain barrier (molecules <500 Daltons can do so reliably IF they meet other characteristics regarding their shape, lipophilicity (literally love/like of fat, practically how well it mixes with fat --think of oil and vinegar salad dressing!) Haven't reallyhad to use my biochemistry-course gained knowledge of molecular size,weight and lipophobic/lipophilic properties for 30 years--amazing some of it is still in the old lipophylic brain! (I am sure RB has something to say about that) Hope some of this helped...