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Any ER+ her2+ person should read carefully the research on tamoxifen resistance and her2. You can do a search on this site and find alot of information/discussion. After doing extensive reading I would not be on tamoxifen without also being on herceptin, as blocking the estrogen receptor with tamox seems to cause the sneaky cancer cell to upregulate the her2 receptor activity. Recent studies suggests that we need to block both sites at the same time to be effective long term. IMHO
kk1
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