HER2 Support Group Forums - View Single Post - navelbine and cardio-toxicity

Lolly · 02-25-2006, 07:29 PM

OK, last link, I promise!(along with an exercpt):

Cardiac Toxicity
http://patient.cancerconsultants.com....aspx?id=23145

"...There are specific classes of drugs, such as the anthracyclines (doxorubicin, daunomycin, epirubicin, mitoxantrone and idarubicin), that are known to cause damage to the muscle cells of the heart. The anthracyclines are also given with other drugs, such as alkylating agents and vinca alkaloids, which can contribute to heart damage. In addition, radiation therapy to the chest wall or area around the heart can affect the blood vessels supplying the heart, leading to a myocardial infarction or “heart attack”. Since many patients, especially with lymphoma or breast cancer, receive both anthracycline-based chemotherapy and radiation therapy, there may be a cumulative effect on the heart. The following is a brief outline of the major drugs that have been associated with long term complications to the heart..."

Lolly here; And lastly, I think the heart damage experienced by the study group on Herceptin/Navelbine could well have been as a result of the Herceptin, and especially in combo with Navelbine.

02-25-2006, 07:29 PM	#5
Lolly Senior Member Join Date: Aug 2001 Location: Oregon Posts: 1,756	OK, last link, I promise!(along with an exercpt): Cardiac Toxicity http://patient.cancerconsultants.com....aspx?id=23145 "...There are specific classes of drugs, such as the anthracyclines (doxorubicin, daunomycin, epirubicin, mitoxantrone and idarubicin), that are known to cause damage to the muscle cells of the heart. The anthracyclines are also given with other drugs, such as alkylating agents and vinca alkaloids, which can contribute to heart damage. In addition, radiation therapy to the chest wall or area around the heart can affect the blood vessels supplying the heart, leading to a myocardial infarction or “heart attack”. Since many patients, especially with lymphoma or breast cancer, receive both anthracycline-based chemotherapy and radiation therapy, there may be a cumulative effect on the heart. The following is a brief outline of the major drugs that have been associated with long term complications to the heart..." Lolly here; And lastly, I think the heart damage experienced by the study group on Herceptin/Navelbine could well have been as a result of the Herceptin, and especially in combo with Navelbine. Last edited by Lolly; 02-25-2006 at 11:03 PM..