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al from Canada · 02-15-2006, 06:33 PM

Yes, Lapatinib is both an EGFR (HER1) and a HER2 inhibitor. You can be one thing positive and another negative but, some combinations have a propensity for pairing, such as; HER2 and VEGF; HER2 and PTEN; HER2 and PI3K, HER2 and EGFR. Just because your tests don't conform to the "usual' doesn't mean you won't respond to therapy. In fact, even being mildly EGFR + doesn't mean that EGFR inhibitors won't benefit you; because, as I mentioned before, these inhibitors have a way of resensitizing other receptors to targetted therapies.

It's all very complicated stuff and if we new the answers, we might have the disease beat. What is most important is that poeple like yourself keep asking the hard questions so that researchers don't forget to keep looking for the answers.
Take care,
Al

02-15-2006, 06:33 PM	#9
al from Canada Senior Member Join Date: Jul 2005 Location: Ontario, Canada Posts: 722	Yes, Lapatinib is both an EGFR (HER1) and a HER2 inhibitor. You can be one thing positive and another negative but, some combinations have a propensity for pairing, such as; HER2 and VEGF; HER2 and PTEN; HER2 and PI3K, HER2 and EGFR. Just because your tests don't conform to the "usual' doesn't mean you won't respond to therapy. In fact, even being mildly EGFR + doesn't mean that EGFR inhibitors won't benefit you; because, as I mentioned before, these inhibitors have a way of resensitizing other receptors to targetted therapies. It's all very complicated stuff and if we new the answers, we might have the disease beat. What is most important is that poeple like yourself keep asking the hard questions so that researchers don't forget to keep looking for the answers. Take care, Al __________________ Primary care-giver to and advocate for Linda, who passed away April 27, 2006.