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Cathy, I've been taking Herceptin since 2001 and although I had a history of sinus headaches, they were occuring more frequently and with more intensity on Herceptin so I've had brain MRI's twice now to rule out brain mets. So far everything's fine but I will be asking for another brain MRI this year as it will have been a year since my last one.
It's probably just a headache, but if it worries you bring it to your onc's attention and ask for an MRI just to be sure.
<3,
Lolly
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