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This has been a very interesting question for me. My orig dx in Apr of 2001 showed the tumor to be er/pr+. When I went back for second surgery to clear margins they found a tiny isolated tumor that was er/pr-. Even so, they decided tamoxifen would be of benefit to me...NOT SO! When I recurred in 2003 the tumors found in my breast and liver were er/pr-. I am her2+++ and after completing 8 rounds of taxotere/herceptin I continue on herceptin every 3 weeks...indefinately.
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