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Dear Linda -
Your comfort zone is THE most important place to be in this fight. If you are heading into a direction that makes you nervous, veer back to a course you feel more positive about. Getting as much info as possible on the trial and then make your decision.
Personally, I would want to keep with herceptin in whatever combination. That trial would not interest me unless I had a real aggressive change in tumors.
And I am not sure if it is really a question of "ethics" - your life is at stake!
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