HER2 Support Group Forums - View Single Post - THIS MAY BE BIG: new monoclonalantibody-peptide conjugate crosses blood-brainbarrier

Rolepaul · 12-19-2014, 04:15 PM

Funny. I saw this and saw the results on the MRI scans with Nina's brain lesions. Are the researcher's missing something with conjugated antibodies and water/lipid solubility thinking. If the MAb is water soluble and the BBB prevents the MAb penetrating to help by forming a fat film, conjugating the non-water soluble cancer drug may work because it allows the MAb to to get through the BBB, not because it makes the conjugate more deadly to the cancer cell. Maybe the concept is to conjugate a fat like substance, which is cheap versus the cancer drugs. Another thing to ask a MAb guru.

12-19-2014, 04:15 PM	#7
Rolepaul Senior Member Join Date: Jan 2012 Location: Boulder Colorado as of January 2013 Posts: 391	Re: THIS MAY BE BIG: new monoclonalantibody-peptide conjugate crosses blood-brainbar Funny. I saw this and saw the results on the MRI scans with Nina's brain lesions. Are the researcher's missing something with conjugated antibodies and water/lipid solubility thinking. If the MAb is water soluble and the BBB prevents the MAb penetrating to help by forming a fat film, conjugating the non-water soluble cancer drug may work because it allows the MAb to to get through the BBB, not because it makes the conjugate more deadly to the cancer cell. Maybe the concept is to conjugate a fat like substance, which is cheap versus the cancer drugs. Another thing to ask a MAb guru.