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Re: Neratinib
Nancy,
I am watching this closely with my doc at UCSF. The company was hoping to have approval for it in early 2015 but it was pushed back as the FDA wants them to do more animal testing for secondary cancers. She expects a year delay. My breast oncologist (who's husband is a breast oncology researcher at UCSF as well and knows Puma Biotech well) thinks it's an outrageous demand at this stage in the drugs history.
My understanding is that if administered as a single agent, the most common side effect is diarrhea.
I will keep you updated when I know more. I meet w. her in a few months and we are going to discuss its use. Also, initially, they were saying that you need to introduce Neratinib within 3 months of being on Herceptin. That may no longer be there case.
Kathryn
8/13 dx her2+++, pr+, er+, stage 2a, right breast 3 lymph nodes
9/13 bilateralmastectomy
10/13 - 2/14 ac/th, herceptin and perjeta
3/14 6 2weeks radiation
6/14 tamoxifen, tried it and stopped, terrible side effects
7/14 arimidex, tried it. currently taking vacation
exchange surgery scheduled 1/15
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